Ketoprofen

Introduction

Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) used to reduce pain, swelling, and inflammation. It is used to temporarily relieve minor aches and pains caused by various conditions such as muscle strains, toothache, backache, arthritis, menstrual cramps, and other conditions. It may also be used to reduce fever.

Uses

Ketoprofen is used to treat minor aches and pains caused by arthritis, muscle and joint pain, and other conditions. It may also be used to reduce fever and for other purposes not listed in this medication guide.

Brand Name	Ketoprofen
Type
Weight
Generic	Ketoprofen
Manufacturer
Available in	English বাংলা

Mechanism of Action

Ketoprofen works by blocking the production of chemicals that cause inflammation and pain. It also increases the amount of natural substances in the body that reduce pain and inflammation.

How Long Does It Take to Work?

Ketoprofen starts to work quickly. At least some of its effects are usually seen within an hour of taking a dose, and it may continue to reduce pain and inflammation over time.

Absorption

Ketoprofen is absorbed in the stomach and small intestine and is widely distributed throughout the body. Its bioavailability is about 70%.

Route of Elimination

Ketoprofen is eliminated mainly through the kidneys. Less than 1% is excreted unchanged in the urine.

Dosage

Injection-
Cattle:

• For deep intramuscular or intravenous use. 1 ml/33 kg body weight (3 mg/kg body weight) once daily for 3 days.

Horse:

• For musculoskeletal disorder: 1 ml/45 kg body weight (2.2 mg /kg) by intravenous injection once daily
• for 3 to 5 days.
• For equine colic: 1 ml/45 kg body weight (2.2 mg/kg) by intravenous injection. A second injection may be given if colic recurs.

Bolus-

• Cattle: 1 bolus per 100 kg body weight (4 mg/kg) orally daily for upto 3 days. Or As directed by the Veterinary physician.

The usual adult dose of ketoprofen is 200-400 mg per day in divided doses. The dose may be increased to 1200 mg/day in divided doses if needed. For children, the dose is based on age and weight. Consult your doctor for specific dosage recommendations.

Administration

Ketoprofen is usually taken by mouth with or without food. It may also be used as an injection or topical cream. Follow your doctor's instructions carefully.

Side Effects

The most common side effects of ketoprofen are nausea, vomiting, abdominal pain, and headache. Other possible side effects include dizziness, drowsiness, rashes, and allergic reactions. In rare cases, it can cause kidney damage or abdominal bleeding.

Toxicity

Ketoprofen is generally considered safe and has an acceptable therapeutic index. However, long-term use can increase the risk of serious side effects such as liver and kidney damage, gastrointestinal bleeding, and increased bleeding risk.

Precaution

Ketoprofen may interact with other medications and should be taken with caution. Tell your doctor about any drugs you are taking, including over-the-counter medications, herbal remedies, or supplements. Do not take this medication more than directed.

Interactions

Ketoprofen can interact with other drugs, including aspirin and warfarin (Coumadin). It can also interact with other NSAIDs, such as ibuprofen or naproxen. Talk to your doctor before taking ketoprofen if you are taking any other medications, including over-the-counter medications, herbal remedies, or supplements.

Disease Interactions

Ketoprofen should be used with caution in people with kidney or liver disease, heart disease, asthma, or gastrointestinal disease. It can also increase the risk of bleeding in people with bleeding disorders.

Drug Interactions

Ketoprofen can interact with other drugs, including aspirin and warfarin (Coumadin). It can also interact with other NSAIDs, such as ibuprofen or naproxen. Talk to your doctor before taking ketoprofen if you are taking any other medications, including over-the-counter medications, herbal remedies, or supplements.

Food Interactions

Grapefruit and grapefruit juice may interact with ketoprofen, increasing the risk of side effects. Ask your doctor or pharmacist before taking any other medications or supplements.

Pregnancy Use

Ketoprofen is usually not recommended for pregnant women. Talk to your doctor before using this medication if you are pregnant.

Lactation Use

Ketoprofen should not be used if you are breastfeeding or planning to breastfeed. Talk to your doctor before using this medication if you are breastfeeding.

Acute Overdose

A single overdose of ketoprofen is unlikely to cause serious harm. Symptoms of an overdose include nausea, vomiting, stomach pain, and dizziness. If an overdose is suspected, seek immediate medical attention.

Contraindication

Ketoprofen is contraindicated in people with a known allergy to the drug. It should also be avoided in people with severe kidney impairment, bleeding disorders, stomach ulcers, and those taking anticoagulants. Talk to your doctor before taking ketoprofen.

Use Direction

Take ketoprofen exactly as prescribed by your doctor. Do not take more or less of the medication than directed. Follow the directions on the label or your prescription carefully. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Storage Condition

Store at room temperature away from moisture and heat. Do not freeze. Keep the medication in an airtight container or package.

Volume of Distribution

Ketoprofen is widely distributed throughout the body, with an apparent volume of distribution of about 3.1 L/kg.

Half Life

Ketoprofen has a half-life of approximately 3-5 hours.

Clearance

Ketoprofen 's clearance is about 18.9 mL/min/kg.

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Some Frequently Asked Questions About Ketoprofen